Chapter 10: Male breast cancer

Male Breast Cancer (MBC) accounts for 1% of breast cancers. Male breast cancer mainly occurs due to hormonal imbalance and gene changes (mutations). Risk factors for MBC includes age, genetic mutations, radiation therapy, chemotherapy, family history of breast cancer, high oestrogen exposure…etc. The genetic background of male breast cancer is very different from female breast cancer. Most common genes that have been associated with MBC includes BRCA1&2, PALB2, CHEK2, and ATM genes. Most common clinical features of male breast cancer are lump formation, nipple discharge, inversion of nipple, skin dimpling and redness in the breast region. In this chapter, we have described male breast cancer (MBC) in a detailed manner and some interesting cases reports and research studies reported across the globe.